Pipeline for the identification and classification of ion channels in parasitic flatworms.
Identifieur interne : 000B82 ( Main/Exploration ); précédent : 000B81; suivant : 000B83Pipeline for the identification and classification of ion channels in parasitic flatworms.
Auteurs : Bahiyah Nor [Australie] ; Neil D. Young [Australie] ; Pasi K. Korhonen [Australie] ; Ross S. Hall [Australie] ; Patrick Tan ; Andrew Lonie [Australie] ; Robin B. Gasser [Australie]Source :
- Parasites & vectors [ 1756-3305 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- classification : Canaux ioniques.
- enzymologie : Plathelminthes.
- génétique : Canaux ioniques, Plathelminthes.
- méthodes : Biologie informatique, Parasitologie.
- Animaux.
English descriptors
- KwdEn :
- MESH :
- chemical , classification : Ion Channels.
- chemical , genetics : Ion Channels.
- enzymology : Platyhelminths.
- genetics : Platyhelminths.
- methods : Computational Biology, Parasitology.
- Animals.
Abstract
BACKGROUND
Ion channels are well characterised in model organisms, principally because of the availability of functional genomic tools and datasets for these species. This contrasts the situation, for example, for parasites of humans and animals, whose genomic and biological uniqueness means that many genes and their products cannot be annotated. As ion channels are recognised as important drug targets in mammals, the accurate identification and classification of parasite channels could provide major prospects for defining unique targets for designing novel and specific anti-parasite therapies. Here, we established a reliable bioinformatic pipeline for the identification and classification of ion channels encoded in the genome of the cancer-causing liver fluke Opisthorchis viverrini, and extended its application to related flatworms affecting humans.
METHODS
We built an ion channel identification + classification pipeline (called MuSICC), employing an optimised support vector machine (SVM) model and using the Kyoto Encyclopaedia of Genes and Genomes (KEGG) classification system. Ion channel proteins were first identified and grouped according to amino acid sequence similarity to classified ion channels and the presence and number of ion channel-like conserved and transmembrane domains. Predicted ion channels were then classified to sub-family using a SVM model, trained using ion channel features.
RESULTS
Following an evaluation of this pipeline (MuSICC), which demonstrated a classification sensitivity of 95.2 % and accuracy of 70.5 % for known ion channels, we applied it to effectively identify and classify ion channels in selected parasitic flatworms.
CONCLUSIONS
MuSICC provides a practical and effective tool for the identification and classification of ion channels of parasitic flatworms, and should be applicable to a broad range of organisms that are evolutionarily distant from taxa whose ion channels are functionally characterised.
DOI: 10.1186/s13071-016-1428-2
PubMed: 26983991
PubMed Central: PMC4794918
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pipeline for the identification and classification of ion channels in parasitic flatworms.</title><author><name sortKey="Nor, Bahiyah" sort="Nor, Bahiyah" uniqKey="Nor B" first="Bahiyah" last="Nor">Bahiyah Nor</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Young, Neil D" sort="Young, Neil D" uniqKey="Young N" first="Neil D" last="Young">Neil D. Young</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. nyoung@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Korhonen, Pasi K" sort="Korhonen, Pasi K" uniqKey="Korhonen P" first="Pasi K" last="Korhonen">Pasi K. Korhonen</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hall, Ross S" sort="Hall, Ross S" uniqKey="Hall R" first="Ross S" last="Hall">Ross S. Hall</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tan, Patrick" sort="Tan, Patrick" uniqKey="Tan P" first="Patrick" last="Tan">Patrick Tan</name><affiliation><nlm:affiliation>Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Republic of Singapore.</nlm:affiliation><wicri:noCountry code="subField">Republic of Singapore</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, 138672, Republic of Singapore.</nlm:affiliation><wicri:noCountry code="subField">Republic of Singapore</wicri:noCountry></affiliation></author><author><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><affiliation wicri:level="4"><nlm:affiliation>Victorian Life Sciences Computation Initiative (VLSCI), The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Life Sciences Computation Initiative (VLSCI), The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Gasser, Robin B" sort="Gasser, Robin B" uniqKey="Gasser R" first="Robin B" last="Gasser">Robin B. Gasser</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. robinbg@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26983991</idno><idno type="pmid">26983991</idno><idno type="doi">10.1186/s13071-016-1428-2</idno><idno type="pmc">PMC4794918</idno><idno type="wicri:Area/Main/Corpus">000C08</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C08</idno><idno type="wicri:Area/Main/Curation">000C08</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000C08</idno><idno type="wicri:Area/Main/Exploration">000C08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pipeline for the identification and classification of ion channels in parasitic flatworms.</title><author><name sortKey="Nor, Bahiyah" sort="Nor, Bahiyah" uniqKey="Nor B" first="Bahiyah" last="Nor">Bahiyah Nor</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Young, Neil D" sort="Young, Neil D" uniqKey="Young N" first="Neil D" last="Young">Neil D. Young</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. nyoung@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Korhonen, Pasi K" sort="Korhonen, Pasi K" uniqKey="Korhonen P" first="Pasi K" last="Korhonen">Pasi K. Korhonen</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hall, Ross S" sort="Hall, Ross S" uniqKey="Hall R" first="Ross S" last="Hall">Ross S. Hall</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tan, Patrick" sort="Tan, Patrick" uniqKey="Tan P" first="Patrick" last="Tan">Patrick Tan</name><affiliation><nlm:affiliation>Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Republic of Singapore.</nlm:affiliation><wicri:noCountry code="subField">Republic of Singapore</wicri:noCountry></affiliation><affiliation><nlm:affiliation>Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, 138672, Republic of Singapore.</nlm:affiliation><wicri:noCountry code="subField">Republic of Singapore</wicri:noCountry></affiliation></author><author><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><affiliation wicri:level="4"><nlm:affiliation>Victorian Life Sciences Computation Initiative (VLSCI), The University of Melbourne, Parkville, Victoria, 3010, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Victorian Life Sciences Computation Initiative (VLSCI), The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Gasser, Robin B" sort="Gasser, Robin B" uniqKey="Gasser R" first="Robin B" last="Gasser">Robin B. Gasser</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. robinbg@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Parasites & vectors</title><idno type="eISSN">1756-3305</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Computational Biology (methods)</term><term>Ion Channels (classification)</term><term>Ion Channels (genetics)</term><term>Parasitology (methods)</term><term>Platyhelminths (enzymology)</term><term>Platyhelminths (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Biologie informatique (méthodes)</term><term>Canaux ioniques (classification)</term><term>Canaux ioniques (génétique)</term><term>Parasitologie (méthodes)</term><term>Plathelminthes (enzymologie)</term><term>Plathelminthes (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="classification" xml:lang="en"><term>Ion Channels</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ion Channels</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="fr"><term>Canaux ioniques</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Plathelminthes</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Platyhelminths</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Platyhelminths</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux ioniques</term><term>Plathelminthes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term><term>Parasitology</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Biologie informatique</term><term>Parasitologie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Ion channels are well characterised in model organisms, principally because of the availability of functional genomic tools and datasets for these species. This contrasts the situation, for example, for parasites of humans and animals, whose genomic and biological uniqueness means that many genes and their products cannot be annotated. As ion channels are recognised as important drug targets in mammals, the accurate identification and classification of parasite channels could provide major prospects for defining unique targets for designing novel and specific anti-parasite therapies. Here, we established a reliable bioinformatic pipeline for the identification and classification of ion channels encoded in the genome of the cancer-causing liver fluke Opisthorchis viverrini, and extended its application to related flatworms affecting humans.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We built an ion channel identification + classification pipeline (called MuSICC), employing an optimised support vector machine (SVM) model and using the Kyoto Encyclopaedia of Genes and Genomes (KEGG) classification system. Ion channel proteins were first identified and grouped according to amino acid sequence similarity to classified ion channels and the presence and number of ion channel-like conserved and transmembrane domains. Predicted ion channels were then classified to sub-family using a SVM model, trained using ion channel features.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Following an evaluation of this pipeline (MuSICC), which demonstrated a classification sensitivity of 95.2 % and accuracy of 70.5 % for known ion channels, we applied it to effectively identify and classify ion channels in selected parasitic flatworms.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>MuSICC provides a practical and effective tool for the identification and classification of ion channels of parasitic flatworms, and should be applicable to a broad range of organisms that are evolutionarily distant from taxa whose ion channels are functionally characterised.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26983991</PMID><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1756-3305</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><PubDate><Year>2016</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Parasites & vectors</Title><ISOAbbreviation>Parasit Vectors</ISOAbbreviation></Journal><ArticleTitle>Pipeline for the identification and classification of ion channels in parasitic flatworms.</ArticleTitle><Pagination><MedlinePgn>155</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13071-016-1428-2</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Ion channels are well characterised in model organisms, principally because of the availability of functional genomic tools and datasets for these species. This contrasts the situation, for example, for parasites of humans and animals, whose genomic and biological uniqueness means that many genes and their products cannot be annotated. As ion channels are recognised as important drug targets in mammals, the accurate identification and classification of parasite channels could provide major prospects for defining unique targets for designing novel and specific anti-parasite therapies. Here, we established a reliable bioinformatic pipeline for the identification and classification of ion channels encoded in the genome of the cancer-causing liver fluke Opisthorchis viverrini, and extended its application to related flatworms affecting humans.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We built an ion channel identification + classification pipeline (called MuSICC), employing an optimised support vector machine (SVM) model and using the Kyoto Encyclopaedia of Genes and Genomes (KEGG) classification system. Ion channel proteins were first identified and grouped according to amino acid sequence similarity to classified ion channels and the presence and number of ion channel-like conserved and transmembrane domains. Predicted ion channels were then classified to sub-family using a SVM model, trained using ion channel features.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Following an evaluation of this pipeline (MuSICC), which demonstrated a classification sensitivity of 95.2 % and accuracy of 70.5 % for known ion channels, we applied it to effectively identify and classify ion channels in selected parasitic flatworms.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MuSICC provides a practical and effective tool for the identification and classification of ion channels of parasitic flatworms, and should be applicable to a broad range of organisms that are evolutionarily distant from taxa whose ion channels are functionally characterised.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nor</LastName><ForeName>Bahiyah</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Neil D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. nyoung@unimelb.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korhonen</LastName><ForeName>Pasi K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Ross S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Genome Institute of Singapore, 60 Biopolis Street, Singapore, 138672, Republic of Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, 138672, Republic of Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lonie</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Victorian Life Sciences Computation Initiative (VLSCI), The University of Melbourne, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gasser</LastName><ForeName>Robin B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, 3010, Australia. robinbg@unimelb.edu.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parasit Vectors</MedlineTA><NlmUniqueID>101462774</NlmUniqueID><ISSNLinking>1756-3305</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007473">Ion Channels</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007473" MajorTopicYN="N">Ion Channels</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010274" MajorTopicYN="N">Parasitology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010986" MajorTopicYN="N">Platyhelminths</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bioinformatic pipeline</Keyword><Keyword MajorTopicYN="N">Classification</Keyword><Keyword MajorTopicYN="N">Identification</Keyword><Keyword MajorTopicYN="N">Ion channels</Keyword><Keyword MajorTopicYN="N">Parasitic flatworms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26983991</ArticleId><ArticleId IdType="doi">10.1186/s13071-016-1428-2</ArticleId><ArticleId IdType="pii">10.1186/s13071-016-1428-2</ArticleId><ArticleId IdType="pmc">PMC4794918</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Physiol Rev. 2003 Apr;83(2):377-415</Citation><ArticleIdList><ArticleId IdType="pubmed">12663863</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2014 Jan;42(Database issue):D553-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24316578</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2001 Jan 19;305(3):567-80</Citation><ArticleIdList><ArticleId IdType="pubmed">11152613</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2000 Jan 1;28(1):27-30</Citation><ArticleIdList><ArticleId IdType="pubmed">10592173</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2003 Jun 6;278(23):20890-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12672827</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 Nov 12;285(46):35878-88</Citation><ArticleIdList><ArticleId IdType="pubmed">20826800</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2006 Dec;5(12):993-6</Citation><ArticleIdList><ArticleId IdType="pubmed">17139284</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Mol Pathol. 2007 Apr;82(2):104-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17398281</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2012 Feb;44(2):221-5</Citation><ArticleIdList><ArticleId IdType="pubmed">22246508</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 2009 Oct;136(12):1593-610</Citation><ArticleIdList><ArticleId IdType="pubmed">19627633</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitol Res. 2004 Nov;94(5):329-31</Citation><ArticleIdList><ArticleId IdType="pubmed">15449179</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Negl Trop Dis. 2012 Jan;6(1):e1455</Citation><ArticleIdList><ArticleId IdType="pubmed">22253936</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 1997 May 29;336(22):1575-86</Citation><ArticleIdList><ArticleId IdType="pubmed">9164815</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 2005;131 Suppl:S97-108</Citation><ArticleIdList><ArticleId IdType="pubmed">16569296</ArticleId></ArticleIdList></Reference><Reference><Citation>Korean J Parasitol. 2003 Jun;41(2):129-33</Citation><ArticleIdList><ArticleId IdType="pubmed">12815327</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2004 Nov;6(11):1039-47</Citation><ArticleIdList><ArticleId IdType="pubmed">15516997</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2006 Jul 1;22(13):1658-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16731699</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2013;9(8):e1003586</Citation><ArticleIdList><ArticleId IdType="pubmed">24009509</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2014;5:4378</Citation><ArticleIdList><ArticleId IdType="pubmed">25007141</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2006 Jan 1;34(Database issue):D267-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16381861</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2011 Jan;39(Database issue):D362-6</Citation><ArticleIdList><ArticleId IdType="pubmed">20972209</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2014 May 1;30(9):1236-40</Citation><ArticleIdList><ArticleId IdType="pubmed">24451626</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(1):e54732</Citation><ArticleIdList><ArticleId IdType="pubmed">23382950</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Dev Biol. 2012;56(1-3):5-17</Citation><ArticleIdList><ArticleId IdType="pubmed">22450992</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 2006 Jul;133(Pt 1):67-74</Citation><ArticleIdList><ArticleId IdType="pubmed">16566851</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Infect Dis. 2007 Oct;20(5):489-94</Citation><ArticleIdList><ArticleId IdType="pubmed">17762782</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Neurosci. 1994;17:569-602</Citation><ArticleIdList><ArticleId IdType="pubmed">7516126</ArticleId></ArticleIdList></Reference><Reference><Citation>Philos Trans R Soc Lond B Biol Sci. 2008 Apr 27;363(1496):1513-22</Citation><ArticleIdList><ArticleId IdType="pubmed">18192183</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2014 Jun;10(6):e1004181</Citation><ArticleIdList><ArticleId IdType="pubmed">24945827</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Parasitol Drugs Drug Resist. 2013 Dec 11;4(1):48-54</Citation><ArticleIdList><ArticleId IdType="pubmed">24596668</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasit Vectors. 2014;7:224</Citation><ArticleIdList><ArticleId IdType="pubmed">24885060</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Sci. 2014;15(7):12940-51</Citation><ArticleIdList><ArticleId IdType="pubmed">25054318</ArticleId></ArticleIdList></Reference><Reference><Citation>J Comput Chem. 2007 Jul 15;28(9):1463-6</Citation><ArticleIdList><ArticleId IdType="pubmed">17330882</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 2001 Sep;17(9):847-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11590104</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Jul 16;460(7253):352-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19606141</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2014 Jan;42(Database issue):D222-30</Citation><ArticleIdList><ArticleId IdType="pubmed">24288371</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2005 Jan;5(1):31-41</Citation><ArticleIdList><ArticleId IdType="pubmed">15620559</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioinformatics. 1998;14(9):755-63</Citation><ArticleIdList><ArticleId IdType="pubmed">9918945</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochimie. 2015 Jan;108:149-59</Citation><ArticleIdList><ArticleId IdType="pubmed">25461277</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 1990 Oct 5;215(3):403-10</Citation><ArticleIdList><ArticleId IdType="pubmed">2231712</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2004 Oct 1;279(40):41650-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15292267</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2014 Jun 28;383(9936):2253-64</Citation><ArticleIdList><ArticleId IdType="pubmed">24698483</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Apr 4;496(7443):57-63</Citation><ArticleIdList><ArticleId IdType="pubmed">23485966</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Trop. 2011 Sep;120 Suppl 1:S158-68</Citation><ArticleIdList><ArticleId IdType="pubmed">20655862</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2015 Jan;43(Database issue):D1057-63</Citation><ArticleIdList><ArticleId IdType="pubmed">25378336</ArticleId></ArticleIdList></Reference><Reference><Citation>Genome Biol. 2014;15(10):466</Citation><ArticleIdList><ArticleId IdType="pubmed">25315136</ArticleId></ArticleIdList></Reference><Reference><Citation>Genomics Proteomics Bioinformatics. 2006 Nov;4(4):253-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17531801</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pharmacogenomics. 2005;5(6):387-96</Citation><ArticleIdList><ArticleId IdType="pubmed">16336003</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1981 Jun;78(6):3824-8</Citation><ArticleIdList><ArticleId IdType="pubmed">6167991</ArticleId></ArticleIdList></Reference><Reference><Citation>J Theor Biol. 2011 Jan 21;269(1):64-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20969879</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 1995 Feb;110 ( Pt 2):171-80</Citation><ArticleIdList><ArticleId IdType="pubmed">7533899</ArticleId></ArticleIdList></Reference><Reference><Citation>ScientificWorldJournal. 2015;2015:945927</Citation><ArticleIdList><ArticleId IdType="pubmed">25961077</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann N Y Acad Sci. 1999 Apr 30;868:233-85</Citation><ArticleIdList><ArticleId IdType="pubmed">10414301</ArticleId></ArticleIdList></Reference><Reference><Citation>Anal Biochem. 2008 Feb 15;373(2):386-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17976365</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2010 Apr;23(2):442-66</Citation><ArticleIdList><ArticleId IdType="pubmed">20375361</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Pharmacol Toxicol. 1997;37:205-37</Citation><ArticleIdList><ArticleId IdType="pubmed">9131252</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Parasitol. 2005 Jan;35(1):1-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15619510</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 2013 Feb;168(3):554-75</Citation><ArticleIdList><ArticleId IdType="pubmed">22994528</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Physiol. 2008;8:6</Citation><ArticleIdList><ArticleId IdType="pubmed">18366784</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Jul 16;460(7253):345-51</Citation><ArticleIdList><ArticleId IdType="pubmed">19606140</ArticleId></ArticleIdList></Reference><Reference><Citation>Physiol Rev. 2002 Oct;82(4):1013-67</Citation><ArticleIdList><ArticleId IdType="pubmed">12270951</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12</Citation><ArticleIdList><ArticleId IdType="pubmed">25348405</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Infect. 2015 May;21(5):433-43</Citation><ArticleIdList><ArticleId IdType="pubmed">25911990</ArticleId></ArticleIdList></Reference><Reference><Citation>Proteins. 2001 May 15;43(3):246-55</Citation><ArticleIdList><ArticleId IdType="pubmed">11288174</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2014 Jan;42(Database issue):D199-205</Citation><ArticleIdList><ArticleId IdType="pubmed">24214961</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2014 Jan;42(Database issue):D191-8</Citation><ArticleIdList><ArticleId IdType="pubmed">24253303</ArticleId></ArticleIdList></Reference><Reference><Citation>Parasitology. 2007 Jun;134(Pt 6):833-40</Citation><ArticleIdList><ArticleId IdType="pubmed">17214911</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Tan, Patrick" sort="Tan, Patrick" uniqKey="Tan P" first="Patrick" last="Tan">Patrick Tan</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Nor, Bahiyah" sort="Nor, Bahiyah" uniqKey="Nor B" first="Bahiyah" last="Nor">Bahiyah Nor</name></region><name sortKey="Gasser, Robin B" sort="Gasser, Robin B" uniqKey="Gasser R" first="Robin B" last="Gasser">Robin B. Gasser</name><name sortKey="Hall, Ross S" sort="Hall, Ross S" uniqKey="Hall R" first="Ross S" last="Hall">Ross S. Hall</name><name sortKey="Korhonen, Pasi K" sort="Korhonen, Pasi K" uniqKey="Korhonen P" first="Pasi K" last="Korhonen">Pasi K. Korhonen</name><name sortKey="Lonie, Andrew" sort="Lonie, Andrew" uniqKey="Lonie A" first="Andrew" last="Lonie">Andrew Lonie</name><name sortKey="Young, Neil D" sort="Young, Neil D" uniqKey="Young N" first="Neil D" last="Young">Neil D. Young</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SanteMusiqueV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SanteMusiqueV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26983991
|texte= Pipeline for the identification and classification of ion channels in parasitic flatworms.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26983991" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SanteMusiqueV1
| This area was generated with Dilib version V0.6.38. |  |